Coenzyme A, Free acid

Coenzyme A (CoA) is a universal metabolic cofactor synthesized from cysteine, pantothenate, and ATP. It is notable for its role in the synthesis and oxidation of fatty acids and the oxidation of pyruvate in the citric acid cycle (Leonardi et al., 2005). All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it, or a thioester form of it, as a substrate (Sibon & Strauss, 2016).

 

Applications

 

Coenzyme A (CoA) Free Acid is widely used in biochemical research and drug development due to its role as a cofactor in numerous enzymatic reactions, particularly in acyl group transfer processes. It is extensively applied in studies of metabolic pathways, such as the citric acid cycle and fatty acid metabolism, to explore enzyme functions, regulatory mechanisms, and potential therapeutic targets (Leonardi et al., 2005). CoA Free Acid is also valuable in drug discovery for evaluating inhibitors or activators of CoA-dependent enzymes, which are crucial for developing treatments for metabolic disorders and infections (Spry et al., 2008).